Resveratrol is a natural compound found in certain plants, particularly in the skin of red grapes, red wine, peanuts, and some berries. It belongs to a class of compounds called polyphenols, which act as antioxidants in the body. Resveratrol has gained attention due to its health benefits, and it is often associated with the "French Paradox", a phenomenon where the French population has a relatively low incidence of heart disease despite a diet rich in saturated fats. Resveratrol has been studied for its ability activate a group of proteins known as sirtuins, specifically SIRT1. SIRT1, in particular, is associated with cellular health, energy regulation, and the promotion of longevity. Resveratrol is thought to mimic the effects of caloric restriction, a dietary intervention that has been linked to increased lifespan.

Sirtuins are a family of 7 proteins that help regulate our cellular health. They play an important role in ageing. However, sirtuins can only function in the presence of NAD+. Out of the seven sirtuins in the cell, three of them work in the mitochondria, three of them work in the nucleus and one of them works in the cytoplasm, each playing a variety of role. In our cells, there are many compounds performing various tasks but all have the ultimate goal — stay healthy and function efficiently for as long as possible. Sirtuins play the role of determining what needs to be done and when. However, they can’t operate on their own as sirtuins need NAD+ to function. Dr. David Sinclair has recognised Sirtuins as the 'master regulators of defenses against age-related disease', and when we tweak the SIRT1 gene, it makes the whole body more robust and fitter.

Sirtuins are involved in the regulation of many fundamental biological processes thoughout the body. They are special proteins that are NAD+ dependent, and require NAD+ for fuel and they are essential in delaying cellular senescence and extending lifespan. They regulate the pathways that control cellular death; they turn anti-ageing genes on and off; repair DNA and regulate our metabolism. Sirtuins are crucial cellular proteins that hold sway over a broad range of physiological processes. As such, they present a promising therapeutic strategy to mitigate age-related diseases and extend your health span. The main way Sirtuins are activated is through hot & cold stress & Calorie restriction (CR). CR is by far the most effective intervention, genetic or environmental, for slowing down ageing in mammals.

Resveratrol Increases your Sirtuin activity with the unique formulation of Trans-Resveratrol, Curcumin, Quercetin, and BioPerine. It is designed to optimise bioavailability of Resveratrol (350%) and Curcumin (229%), allowing your body to experience the natural benefits that enhance your body's best defence against premature ageing. This would equate to one serving as 900mg of Trans-Resveratrol, 658mg of Curcumin and 400mg of Quercetin.

Increased Sirtuin activity could mimic Calorie Restriction (CR) and help to regulate epigenetic modifications. It could assist in delaying cellular senescence, improving cardiovascular function. Increased Sirtuin activity may also assist in regulating neurological function, and inflammatory and stress Response.

We recommend to take NMN and Resveratrol together for enhanced effects as they have a synergetic effect. NMN boosts NAD+ levels, crucial for energy production and cellular function, whilst Resveratrol activates the Sirtuin genes, associated with longevity and regulating cellular processes. Together, they enhance each other's effects on cellular energy production and repair mechanisms. This combined action could offer better cellular protection and support against aging-related decline.