Sirtuins, is a key players in conferring the longevity and health benefits of calorie restriction. Resveratrol, the wine ingredient, is thought to rev up one of the sirtuins, SIRT1, which appears to help protect mice on high doses of resveratrol from the ill effects of high-fat diets. A slew of other health benefits have been attributed to SIRT1 activation in hundreds of studies, including several human trials.
It is reported that NAD fuels the activity of sirtuins, including SIRT1—the more NAD there is in cells, the more SIRT1 does beneficial things. One of those things is to induce formation of new mitochondria. NAD can also activate another sirtuin, SIRT3, which is thought to keep mitochondria running smoothly.
The Sinclair paper drew attention partly because it showed a novel way that NAD and sirtuin work together. The researchers discovered that cells' nuclei send signals to mitochondria that are needed to maintain their normal operation. SIRT1 helps ensure the signals get through. When NAD levels drop, as they do with aging, SIRT1 activity falls off, which in turn makes the crucial signals fade, leading to mitochondrial dysfunction and all the ill effects that go with it.
Short for Nicotinamide Adenine Dinucleotide, NAD, was discovered in 1906 and is a coenzyme found in all our living cells.
NAD is one of the earliest molecules on earth and is found in every cell of the body. It plays a key role in protecting the major organs of the body. So as NAD declines, so does that protection.
It is reported that NAD fuels the activity of sirtuins, including SIRT1—the more NAD there is in cells, the more SIRT1 does beneficial things. One of those things is to induce formation of new mitochondria. NAD can also activate another sirtuin, SIRT3, which is thought to keep mitochondria running smoothly.
NAD+ is the natural fuel every cell in our body relies on. As we age our natural defenses and ability to formulate NAD+ drop significantly, resulting in significant reduction in quality of life with age.
Acute stress, exercise and calorie restriction can create natural NAD+.
Supplements like NMN & NR boost NAD to youthful levels which then act as fuel for the Sirtuin gene.
It takes two to tango and Sirtuins function at their best when NAD+ levels are at youthful levels.
Supplements like Resveratrol & Curcumin act as an accelerator pedal to the Sirtuins gene to increate activation.
Acute stress, exercise and calorie restriction can create natural NAD+.
Supplements like NMN & NR boost NAD to youthful levels which then act as fuel for the Sirtuin gene.
It takes two to tango and Sirtuins function at their best when NAD+ levels are at youthful levels.
Supplements like Resveratrol & Curcumin act as an accelerator pedal to the Sirtuins gene to increate activation.
Sirtuins consist seven protein molecules that are like members of a family or a group. Experts claim that our bodies are made up of at least 60,000 families of protein. The sirtuins family is one of them. Each member of the sirtuin family is located in different parts of the cell and has a different role to play, but all of them play a protective role in preventing damage to our DNA.
Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.
Sirtuins are known as one of the pathways to longevity because of the essential role that they play in our bodies. Some of these functions include:
Epigenetics refers to external changes (modifications) to DNA that switch genes “off” and “on.” It’s the reason why cells in our skin look different to cells in our muscles. These cells contain the same DNA, but the genes are expressed differently.
Sirtuins are responsible for epigenetic modifications and building the connection between metabolism and epigenetics.
Research has shown that the manipulation of sirtuins could benefit lifespan due to epigenetic changes.
When a cell becomes cancerous, cellular processes become abnormal. Sirtuins play an important role in regulating cellular processes such as cellular metabolism, maintaining chromatin structure, and maintaining genomic stability.
All of these processes become negatively affected when a cell is cancerous. Therefore, sirtuins can help minimize the risk of cancer, which, as we already know, is one of the leading causes of early death and poor quality of life.
When a cell becomes cancerous, cellular processes become abnormal. Sirtuins play an important role in regulating cellular processes such as cellular metabolism, maintaining chromatin structure, and maintaining genomic stability.
All of these processes become negatively affected when a cell is cancerous. Therefore, sirtuins can help minimize the risk of cancer, which, as we already know, is one of the leading causes of early death and poor quality of life.
Sirtuins can also boost cardiovascular function by inhibiting oxidative stress (cell damage caused by free radicals), regulating blood pressure, and ensuring homeostasis (a balanced cell environment) under stress and physiological conditions. Cardiovascular disease is one of the leading causes of early death. Therefore sirtuins can play an important role in preventing cardiovascular disease.
By increasing NAD+ levels, we can increase the functioning of sirtuins, which boosts our metabolism.
Another way through which sirtuins promotes longevity is by regulating metabolism.
Sirtuins regulate glucose and fat metabolism in response to physiological changes in energy levels. This helps maintain balanced energy levels and, as such, determines longevity.
Sirtuins play a crucial role in the regulation of brain function. Scientists have found that sirtuins can also boost memory and brainpower.
As we age and NAD+ level falls, the level of sirtuin activity declines which results in prolonged neuroinflammation, which leads to synaptic damage and neuronal death.
Age-related decline in hypothalamic function (the part of the brain that controls body temperature, thirst, hunger, fatigue, sleep, circadian rhythms and some behavioral aspects such as attachment) can be caused by a reduction in SIRT1 activity.
Sirtuins play a crucial role in the regulation of brain function. Scientists have found that sirtuins can also boost memory and brainpower.
As we age and NAD+ level falls, the level of sirtuin activity declines which results in prolonged neuroinflammation, which leads to synaptic damage and neuronal death.
Age-related decline in hypothalamic function (the part of the brain that controls body temperature, thirst, hunger, fatigue, sleep, circadian rhythms and some behavioral aspects such as attachment) can be caused by a reduction in SIRT1 activity.
Sirtuins defend and mend against inflammation and play essential but distinct roles in chronic and acute inflammation. Chronic inflammatory diseases often persist in a “low-sirtuins” state, and increasing SIRT1 levels or activity can be beneficial.
Sirtuins regulate many biological functions in the human body and is “longevity essential.” Without it, life as we know it cannot exist. There is a direct link between premature aging and reduced function of sirtuins.
As they say, “It takes two to tango.” As important as they are, sirtuins cannot function without NAD+, and we have already seen that NAD+ levels lower with age.
However, due to technology and the advancement of human knowledge in science, we now have some power to control how we live and age. We no longer have to leave everything to fate, we can prevent premature aging and slow down the aging process, now that we know how NAD+, sirtuins, and longevity correlate.
Although there are lifestyle adjustments you can make, one of the most effective ways to boost your levels of NAD+ is to supplement with high-quality NMN or our unique, all-natural supplement specifically designed to boost the longevity gene, Preservage. Our unique formula is designed to work deep within the body to slow down the aging process the natural way.
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